Semaglutide and Tirzepatide are the two leading medical weight loss injectables used today. Both are
powerful GLP-1–based medications, but they work differently and can lead to different results
depending on your metabolism, medical history, and goals.
At Longevus Youth Clinic in Altamonte Springs, we use both medications as part of a personalized
metabolic program. This article breaks down the differences so you know which option may be right for
you.
What Is Semaglutide?
Semaglutide is a GLP-1 receptor agonist originally developed for diabetes. It works by:
• Slowing gastric emptying
• Reducing appetite
• Improving blood sugar control
• Decreasing cravings
Most patients lose 10–15% of their body weight with consistent use and lifestyle support.
What Is Tirzepatide?
Tirzepatide is a dual GLP-1 and GIP receptor agonist. This means:
• It suppresses appetite like Semaglutide
• AND increases metabolic efficiency via GIP pathways
Tirzepatide is a dual GLP-1 and GIP receptor agonist. This means:
• It suppresses appetite like Semaglutide
• AND increases metabolic efficiency via GIP pathways
This dual-action mechanism makes Tirzepatide 20–30% more effective than Semaglutide for many
patients.
Average weight loss ranges between 15–22% of total body weight.
Key Differences Between Semaglutide & Tirzepatide
1. Weight Loss Speed
• Semaglutide: gradual, steady
• Tirzepatide: faster and more pronounced
2. Appetite Suppression
• Both work well
• Tirzepatide often reduces cravings more strongly
3. Metabolic Boost
• Semaglutide: stabilizes blood sugar
• Tirzepatide: improves metabolism through dual pathways
4. Side Effects
Most patients tolerate both well. Tirzepatide may cause slightly fewer GI symptoms at low doses.
5. Cost
Semaglutide is generally slightly less expensive, but results may take longer.
Who Is a Good Candidate?
You may qualify if you experience:
• BMI over 27 with weight-related concerns
• Difficulty losing weight despite diet and exercise
• Hormonal imbalance
• Perimenopause or menopause weight gain
• Insulin resistance or PCOS symptoms
Which Medication Should You Choose?
Choose Semaglutide if:
• You prefer a gentler start
• You want a cost-effective option
Choose Tirzepatide if:
• You want faster results
• You have stubborn metabolic resistance
• You prefer stronger appetite control
How Longevus Youth Personalizes Your Weight Loss Plan
At Longevus Youth Clinic, your program includes:
• Customized dosing
• Monthly follow-ups
• Nutritional support
• Optional peptide add-ons
• IV therapy for metabolism
• Hormonal evaluation (if needed)
Final Takeaway
Both medications are excellent tools. The best choice depends on your body, goals, and metabolic
needs. A personalized consultation helps determine which therapy will work best for you.
Ready to Start?
n Call: 407-449-4189
